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KMID : 0385219990090030001
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Korean Journal of Gerontology
1999 Volume.9 No. 3 p.1 ~ p.5
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The Effect of Iron-Overload on Protein Oxidation, Free Radical Generation and Stability of Ferritin
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Song Eun-Sook
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Abstract
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To simulate senescence, we injected FeCl3 in to Sprague-Dawley rat and prepared ferritin from Liver. The amount of ferritin declined slightly, but the iron content of ferritin rose(25%) in iron injected rat. Free radical generation and protein oxidation of ferritin were increased by 100% and 40%, respectively, by iron-overload. Iron release by ferritin was facilitated in iron-overload rat, suggesting higher oxidative stress induced by iron.
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KEYWORD
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Fe, Ferritin, Protein oxidation, Free radical, Stability
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